Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isoforms of apolipoprotein E can modulate tPA-induced clot lysis in vitro.

Frontiers in bioscience : a journal and virtual library - 1 Aug 2002

Clark Joseph F, Huri Daniel A, Carrozzella Janice, Jauch Edward C, Mehta Pritesh, Heaton Daniel, Biehle Susan J, Broderick Joseph P

Abstract excerpt

Apo E, and its respective isoforms, have been linked to outcome and survival in cerebral vascular and cardiovascular diseases. The effectiveness of intravenous tPA in patients with acute ischemic stroke appears to be enhanced in patients who have an Apo E2 phenotype. The ability of Apo E isoproteins (endogenous Apo E isoproteins or exogenous Apo E isoproteins) to modulate tPA-induced clot lysis in vitro was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E2
Share to Apolipoprotein E3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Chromatography, Thin Layer

Share to Fibrinolysis

Share to Mouth Mucosa

Share to Protein Isoforms

Share to Tissue Plasminogen Activator

Source

Identifiers

PMID: 12133811
DOI: 10.2741/A750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isoforms of apolipoprotein E can modulate tPA-induced clot lysis in vitro.PMID 12133811Read ↗

Euglobulin clot lysis induced by tissue type plasminogen activator in subjects with increased levels and different isoforms of lipoprotein (a).Semantic proximity Read ↗

The role of the finger domain of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) in initiation and progression of thrombolysis.Semantic proximity Read ↗

Apolipoprotein E phenotype and the efficacy of intravenous tissue plasminogen activator in acute ischemic stroke.Semantic proximity Read ↗

[ApoE genotype influences on efficacy and safety of thrombolytic treatment for ischemic stroke].Semantic proximity Read ↗

Fibrin clot properties in acute stroke: what differs cerebral hemorrhage from cerebral ischemia?Semantic proximity Read ↗

Variable Resistance to Plasminogen Activator Initiated Fibrinolysis for Intermediate-Risk Pulmonary Embolism.Semantic proximity Read ↗

Studies on the regulation of tissue plasminogen activator activity by physiological templatesSemantic proximity Read ↗

Does apolipoprotein(a) heterogeneity influence lipoprotein(a) effects on fibrinolysis?Semantic proximity Read ↗

In vitro inhibition of fibrinolysis by apolipoprotein(a) and lipoprotein(a) is size- and concentration-dependent.Semantic proximity Read ↗

Real-time measurement of lysis of mural platelet deposits by fibrinolytic agents under arterial flow.Semantic proximity Read ↗

Apolipoprotein E genotype, coagulation, and survival following acute stroke.Semantic proximity Read ↗

Thrombolytic and pharmacokinetic properties of human tissue-type plasminogen activator variants, obtained by deletion and/or duplication of structural/functional domains, in a hamster pulmonary embolism model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.