Article
Apolipoprotein E phenotype and the efficacy of intravenous tissue plasminogen activator in acute ischemic stroke.
Annals of neurology - 1 Jun 2001
Broderick J, Lu M, Jackson C, Pancioli A, Tilley B C, Fagan S C, Kothari R, Levine S R, Marler J R, Lyden P D, Haley E C, Brott T, Grotta J C
Abstract excerpt
We used stored plasma samples from 409 patients in the National Institute of Neurological Diseases and Stroke (NINDS) tissue plasminogen activator (t-PA) Stroke Trial to examine the relationship between an apolipoprotein (Apo) E2 or an Apo E4 phenotype and a favorable outcome 3 months after stroke, the risk of intracerebral hemorrhage, and the response to intravenous t-PA therapy. For the 27 patients with an Apo...
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