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Article

Evidence for crucial electrostatic interactions between Bcl-2 homology domains BH3 and BH4 in the anti-apoptotic Nr-13 protein.

The Biochemical journal - 15 Nov 2002

Lalle Philippe, Aouacheria Abdel, Dumont-Miscopein Agnès, Jambon Martin, Venet Séverine, Bobichon Hélène, Colas Pierre, Deléage Gilbert, Geourjon Christophe, Gillet Germain

Abstract excerpt

Nr-13 is an anti-apoptotic member of the Bcl-2 family previously shown to interact with Bax. The biological significance of this interaction was explored both in yeast and vertebrate cells and revealed that Nr-13 is able to counteract the pro-apoptotic activity of Bax. The Bax-interacting domain has been identified and corresponds to alpha-helices 5 and 6 in Nr-13. Site-directed mutagenesis has revealed that the...

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Identifiers

PMID: 12133006
DOI: 10.1042/BJ20020836
PMCID: PMC1222957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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