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Article

<scp>BH</scp>3‐only proteins: a 20‐year stock‐take

6 Jan 2015

Abstract excerpt

BH3-only proteins are the sentinels of cellular stress, and their activation commits cells to apoptosis. Since the discovery of the first BH3-only protein BAD almost 20 years ago, at least seven more BH3-only proteins have been identified in mammals. They are regulated by a variety of environmental stimuli or by developmental cues, and play a crucial role in cellular homeostasis. Some are considered to be tumor...

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PMID: 25565426
DOI: 10.1111/febs.13190

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