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Article

Molecular subgroups of T-cell acute lymphoblastic leukemia in adults treated according to pediatric-based GMALL protocols.

Leukemia - 1 Jun 2024

Neumann Martin, Beder Thomas, Bastian Lorenz, Hänzelmann Sonja, Bultmann Miriam, Wolgast Nadine, Hartmann Alina, Trautmann Heiko, Ortiz-Tanchez Jutta, Schlee Cornelia, Schroeder Michael, Fransecky Lars, Vosberg Sebastian, Fiedler Walter, Alakel Nael, Heberling Lisa, Kondakci Mustafa, Starck Michael, Schwartz Stefan, Raffel Simon, Müller-Tidow Carsten, Schneller Folker, Reichle Albrecht, Burmeister Thomas, Greif Philipp A, Brüggemann Monika, Gökbuget Nicola, Baldus Claudia D

Abstract excerpt

In contrast to B-cell precursor acute lymphoblastic leukemia (ALL), molecular subgroups are less well defined in T-lineage ALL. Comprehensive studies on molecular T-ALL subgroups have been predominantly performed in pediatric ALL patients. Currently, molecular characteristics are rarely considered for risk stratification. Herein, we present a homogenously treated cohort of 230 adult T-ALL patients characterized...

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Identifiers

PMID: 38744920
DOI: 10.1038/s41375-024-02264-0
PMCID: PMC11147771

Genes

TLX1
LMO2
LYL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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