Article
Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis.
Arthritis and rheumatism - 1 Jul 2002
Shamim Ejaz A, Rider Lisa G, Pandey Janardan P, O'Hanlon Terrance P, Jara Luis J, Samayoa Eduardo A, Burgos-Vargas Ruben, Vazquez-Mellado Janitzia, Alcocer-Varela Jorge, Salazar-Paramo Mario, Kutzbach Abraham Garcia, Malley James D, Targoff Ira N, Garcia-De la Torre Ignacio, Miller Frederick W
Abstract excerpt
OBJECTIVE: As part of a larger, worldwide study of the ethnogeography of myositis, we evaluated the clinical, serologic, and immunogenetic features of Mestizo (Mexican and Guatemalan) and North American Caucasian patients with idiopathic inflammatory myopathy (IIM). METHODS: Clinical manifestations, autoantibodies, HLA-DRB1 and DQA1 alleles, and immunoglobulin Gm/Km allotypes were compared between 138 Mestizos...
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