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Article

Role of type II topoisomerase mutations and AcrAB efflux pump in fluoroquinolone-resistant clinical isolates of Proteus mirabilis.

The Journal of antimicrobial chemotherapy - 1 Sept 2006

Saito Ryoichi, Sato Kenya, Kumita Wakako, Inami Natsuko, Nishiyama Hiroyuki, Okamura Noboru, Moriya Kyoji, Koike Kazuhiko

Abstract excerpt

OBJECTIVES: We conducted a study to determine the role played by amino acid mutations in DNA gyrase and topoisomerase IV, and the AcrAB efflux pump in resistance to fluoroquinolones in clinical isolates of Proteus mirabilis. METHODS: Nine clinical isolates of P. mirabilis containing eight fluoroquinolone-resistant isolates and one fluoroquinolone-susceptible isolate as the causative pathogen were collected from...

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Source

Identifiers

PMID: 16870650
DOI: 10.1093/jac/dkl297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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