Article
Association between interleukin-6 polymorphism and age-at-onset of type 1 diabetes. Epistatic influences of the tumor necrosis factor-alpha and interleukin-1beta polymorphisms.
European cytokine network - 1 Dec 2005
Hermann Csaba, Krikovszky Dóra, Füst George, Kovács Margit, Körner Anna, Szabó András, Vannay Adám, Madácsy László
Abstract excerpt
Multiple immune mediators have been mentioned as playing a role in the pathomechanism of type1 DM. Interleukin (IL)-1beta, and tumor necrosis factor (TNF)-alpha play a central role in the autoimmune destruction of pancreatic beta-cells, whereas IL-6 inhibits TNF-alpha secretion, and may have some protecting effects. In our study, we aimed to investigate the association between these three cytokines' single...
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