Article
Vitamin D receptor (VDR) gene polymorphisms and age onset in type 1 diabetes mellitus.
Autoimmunity - 1 Sept 2013
De Azevêdo Silva Jaqueline, Guimarães Rafael Lima, Brandão Lucas André Cavalcanti, Araujo Jacqueline, Segat Ludovica, Crovella Sergio, Sandrin-Garcia Paula
Abstract excerpt
Vitamin D receptor is a mediator of immune responses through the action of vitamin D, which is capable of regulate the insulin secretion by the pancreas. Since polymorphisms in the vitamin D receptor (VDR) gene might modulate vitamin D function, and thus immunologic response, VDR is possibly able to influence the predisposition to type 1 diabetes mellitus (T1DM). The aim of this work was to perform an association...
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