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Identification of a mutant-like conformation of p53 in fibroblasts from sporadic Alzheimer's disease patients.

Neurobiology of aging - 1 Sept 2006

Uberti Daniela, Lanni Cristina, Carsana Teresina, Francisconi Simona, Missale Cristina, Racchi Marco, Govoni Stefano, Memo Maurizio

Abstract excerpt

Here we show that fibroblasts from sporadic Alzheimer's disease (AD) patients specifically express an anomalous and detectable conformational state of p53 that makes these cells distinct from fibroblasts of age-matched non-AD subjects. In particular, we found that, in contrast to non-AD fibroblasts, p53 in AD fibroblasts is expressed at higher levels in resting condition, and presents a significant impairment of...

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PMID: 16165254
DOI: 10.1016/j.neurobiolaging.2005.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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