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Familial Alzheimer's Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants.

Molecular neurobiology - 1 Sept 2017

Wojsiat Joanna, Laskowska-Kaszub Katarzyna, Alquézar Carolina, Białopiotrowicz Emilia, Esteras Noemi, Zdioruk Mykola, Martin-Requero Angeles, Wojda Urszula

Abstract excerpt

Familial (FAD) and sporadic (SAD) Alzheimer's disease do not share all pathomechanisms, but knowledge on their molecular differences is limited. We previously reported that cell cycle control distinguishes lymphocytes from SAD and FAD patients. Significant differences were found in p21 levels of SAD compared to FAD lymphocytes. Since p21 can also regulate apoptosis, the aim of this study was to compare the...

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Identifiers

PMID: 27644130
DOI: 10.1007/s12035-016-0105-y
PMCID: PMC5533859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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