Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia and adrenergic function: molecular mechanisms related to Egr-1 and Sp1 activation.

Brain research - 24 Sept 2010

Tai T C, Wong-Faull David C, Claycomb Robert, Wong Dona L

Abstract excerpt

Hypoxia is shown to regulate the stress hormone epinephrine through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT) via PNMT gene activation and transcription factors Egr-1 and Sp1 in adrenal medulla-derived PC12 cells. Moderate hypoxia (5% oxygen) markedly stimulates PNMT promo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Hypoxia
Share to Early Growth Response Protein 1
Share to Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PC12 Cells

Share to RNA, Small Interfering

Share to Sp1 Transcription Factor

Share to Transfection

Source

Identifiers

PMID: 20654592
DOI: 10.1016/j.brainres.2010.07.036

Genes

PNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20654592-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia and adrenergic function: molecular mechanisms related to Egr-1 and Sp1 activation.PMID 20654592Read ↗

Why is the adrenal adrenergic?Semantic proximity Read ↗

Phenylethanolamine N-methyltransferase gene expression. Sp1 and MAZ potential for tissue-specific expression.Semantic proximity Read ↗

Regulation of rat dopamine beta-hydroxylase gene transcription by early growth response gene 1 (Egr1).Semantic proximity Read ↗

Hypoxia-induced cell death and changes in hypoxia-inducible factor-1 activity in PC12 cells upon exposure to nerve growth factor.Semantic proximity Read ↗

Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells.Semantic proximity Read ↗

The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation.Semantic proximity Read ↗

In VivoEpinephrine-Mediated Regulation of Gene Expression in Human Skeletal MuscleSemantic proximity Read ↗

β-sitosterol alleviates pulmonary arterial hypertension by altering smooth muscle cell phenotype and DNA damage/cGAS/STING signaling.Semantic proximity Read ↗

Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements.Semantic proximity Read ↗

Effects of Epinephrine on Gastric Adenocarcinoma and Brain Glioblastoma Cancer CellsSemantic proximity Read ↗

Chronic Prenatal Hypoxia Induces Epigenetic Programming of PKCε Gene Repression in Rat HeartsSemantic proximity Read ↗

Phenylethanolamine N-methyltransferase gene polymorphisms and adverse outcomes in acute kidney injury.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.