Article
Enhancement of peroxynitrite-induced apoptosis in PC12 cells by fibroblast growth factor-1 and nerve growth factor requires p21Ras activation and is suppressed by Bcl-2.
Archives of biochemistry and biophysics - 1 Aug 1998
Spear N, Estévez A G, Johnson G V, Bredesen D E, Thompson J A, Beckman J S
Abstract excerpt
Extracellular trophic factors can regulate whether cells subjected to oxidative stress will survive to proliferate or else undergo cell death. We have previously shown that about 35% of undifferentiated PC12 cells undergo apoptosis 18 h after exposure to peroxynitrite and that pretreatment with n...
Topics
- Animals
- Apoptosis
- Drug Synergism
- Fibroblast Growth Factor 1
- Mutation
- Nerve Growth Factors
- Nitrates
- PC12 Cells
- Proto-Oncogene Proteins c-bcl-2
- Proto-Oncogene Proteins p21(ras)
- Rats