Flow cytometric analysis of breast cancer resistance protein expression and function

Abstract excerpt

BACKGROUND: The breast cancer resistance protein (BCRP) is an ATP-binding cassette (ABC) half-transporter that mediates energy-dependent drug efflux. Assessing the clinical relevance of the BCRP will require sensitive and specific methods for detecting its expression and function that allow high-volume specimen throughput and employ widely available instrumentation. METHODS: The BXP-34 and BXP-21 monoclonal...

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