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Article

Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.

International journal of oncology - 1 Nov 2009

Kawaguchi Makiko, Banno Kouji, Yanokura Megumi, Kobayashi Yusuke, Kishimi Arisa, Ogawa Seiji, Kisu Iori, Nomura Hiroyuki, Hirasawa Akira, Susumu Nobuyuki, Aoki Daisuke

Abstract excerpt

Microsatellite instability (MSI) is an indicator of DNA instability and is caused by abnormalities in DNA mismatch repair (MMR) genes such as hMLH1, hMSH2 and hMSH6. MSI occurs frequently in endometrial cancer (in approximately 30% of cases), and accumulation of gene mutations due to MSI may therefore have a major role in the mechanism of malignant transformation. However, a responsible target gene has not been...

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Source

Identifiers

PMID: 19787250
DOI: 10.3892/ijo_00000411

Genes

BAX
EPHB2
HDAC2
MBD4
PTEN

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