Article
A method to detect the G894T polymorphism of the NOS3 gene. Clinical validation in familial hypercholesterolemia.
Clinical chemistry and laboratory medicine - 1 May 2002
Hirata Rosario D C, Salaza Luis A, Cavalli Selma A, Yoshioka Kelson K, Matsumoto Leonardo O, Santos Silverio T, Giannini Sérgio D, Forti Neusa, Diament Jayme, Doi Sonia Q, Hirata Mario H
Abstract excerpt
An endothelial nitric oxide synthase gene (NOS3) polymorphism in exon 7 (G894T), resulting in Glu298Asp substitution at protein level, has been associated with myocardial infarction, hypertension and coronary atherosclerosis in some populations. This polymorphism is usually identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). However, the procedures described to date do not...
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