Association of Glu298Asp Polymorphism of Endothelial NO Synthase Gene with Metabolic Syndrome Development: a Pilot Study.

doi:10.1007/s10517-017-3670-9

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Article

Association of Glu298Asp Polymorphism of Endothelial NO Synthase Gene with Metabolic Syndrome Development: a Pilot Study.

Bulletin of experimental biology and medicine - 1 Mar 2017

Fattakhov N S, Skuratovskaya D A, Vasilenko M A, Kirienkova E V, Zatolokin P A, Mironyuk N I, Litvinova L S

Abstract excerpt

We studied association of single nucleotide polymorphism Glu298Asp (rs1799983) of the NOS3 gene with the risk of metabolic syndrome in the Slavic population. Blood samples were obtained from 128 patients with metabolic syndrome and 100 healthy individuals. Polymorphism Glu298Asp of the NOS3 gene was genotyped by allele-specific PCR. Allele Asp (OR=1.95, 95%CI 1.29-2.95, p=0.007) and genotype Asp/Asp (OR=2.56,...

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PMID: 28361419
DOI: 10.1007/s10517-017-3670-9

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NOS3

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