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Article

Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components

25 Jun 2002

Abstract excerpt

Gliosarcoma is a variant of glioblastoma multiforme characterized by two components displaying gliomatous or sarcomatous differentiation. We investigated 38 gliosarcomas for aberrations of tumor-suppressor genes and proto-oncogenes that are commonly altered in glioblastomas. Amplification of CDK4, MDM2, EGFR, and PDGFRA were found in 11% (4/35), 8% (3/38), 8% (3/38), and 3% (1/35) of the tumors, respectively....

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Identifiers

PMID: 12112531
DOI: 10.1002/gcc.10087

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