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Article

Genetic profile of gliosarcomas.

The American journal of pathology - 1 Feb 2000

Reis R M, Könü-Lebleblicioglu D, Lopes J M, Kleihues P, Ohgaki H

Abstract excerpt

There are distinct genetic pathways leading to the glioblastoma, the most malignant astrocytic brain tumor. Primary (de novo) glioblastomas develop in older patients and are characterized by epidermal growth factor (EGF) receptor amplification/overexpression, p16 deletion, and PTEN mutations, whereas secondary glioblastomas that progressed from low-grade or anaplastic astrocytoma develop in younger patients and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10666371
DOI: 10.1016/S0002-9440(10)64746-3
PMCID: PMC1850048

Genes

CDK4
PTEN
EGF
MDM2
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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