Article
The glial and mesenchymal elements of gliosarcomas share similar genetic alterations.
Journal of neuropathology and experimental neurology - 1 Sept 1996
Boerman R H, Anderl K, Herath J, Borell T, Johnson N, Schaeffer-Klein J, Kirchhof A, Raap A K, Scheithauer B W, Jenkins R B
Abstract excerpt
The cellular origin of the sarcomatous component of gliosarcomas is controversial. It is not clear if the sarcoma arises in transition from the glial cells that comprise the gliomatous component or independently arises from non-neoplastic mesenchymal cells of the tumor stroma. Using comparative genomic hybridization (CGH) along with cytogenetic analysis, fluorescence in situ hybridization (FISH) analysis, and...
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