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Article

Genomic landscape of gliosarcoma: distinguishing features and targetable alterations.

Scientific reports - 9 Sept 2021

Zaki Mark M, Mashouf Leila A, Woodward Eleanor, Langat Pinky, Gupta Saksham, Dunn Ian F, Wen Patrick Y, Nahed Brian V, Bi Wenya Linda

Abstract excerpt

Gliosarcoma is an aggressive brain tumor with histologic features of glioblastoma (GBM) and soft tissue sarcoma. Despite its poor prognosis, its rarity has precluded analysis of its underlying biology. We used a multi-center database to characterize the genomic landscape of gliosarcoma. Sequencing data was obtained from 35 gliosarcoma patients from Genomics Evidence Neoplasia Information Exchange (GENIE) 5.0, a...

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Identifiers

PMID: 34504233
DOI: 10.1038/s41598-021-97454-6
PMCID: PMC8429571

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