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Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing.

Cancer chemotherapy and pharmacology - 1 Sept 2013

Podolski-Renić Ana, Jadranin Milka, Stanković Tijana, Banković Jasna, Stojković Sonja, Chiourea Maria, Aljančić Ivana, Vajs Vlatka, Tešević Vele, Ruždijić Sabera, Gagos Sarantis, Tanić Nikola, Pešić Milica

Abstract excerpt

PURPOSE: Multi-drug resistance (MDR) is a major obstacle to successful cancer treatment. Therefore, in vitro models are necessary for the investigation of the phenotypic changes provoked by cytotoxic agents and more importantly for preclinical testing of new anticancer drugs. METHODS: We analyzed chromosomal, numerical, and structural changes after development of MDR, alterations in p53 and PTEN, single...

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PMID: 23934261
DOI: 10.1007/s00280-013-2247-1

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PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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