Article
Characterization of gene expression induced by RET with MEN2A or MEN2B mutation.
The American journal of pathology - 1 Jul 2002
Watanabe Tsuyoshi, Ichihara Masatoshi, Hashimoto Mizuo, Shimono Keiko, Shimoyama Yoshie, Nagasaka Tetsuro, Murakumo Yoshiki, Murakami Hideki, Sugiura Hideshi, Iwata Hisashi, Ishiguro Naoki, Takahashi Masahide
Abstract excerpt
Germ-line point mutations of the RET gene are responsible for multiple endocrine neoplasia (MEN) type 2A and 2B that develop medullary thyroid carcinoma and pheochromocytoma. We performed a differential display analysis of gene expression using NIH 3T3 cells expressing the RET-MEN2A or RET-MEN2B mutant proteins. As a consequence, we identified 10 genes induced by both mutant proteins and eight genes repressed by...
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