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Article

RET-mediated gene expression pattern is affected by isoform but not oncogenic mutation.

Genes, chromosomes & cancer - 1 May 2009

Hickey Jessica G, Myers Shirley M, Tian Xuefei, Zhu Shu Jun, V Shaw Julie L, Andrew Scott D, Richardson Douglas S, Brettschneider Julia, Mulligan Lois M

Abstract excerpt

The inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN 2) is caused by mutations of the RET receptor tyrosine kinase and is characterized by medullary thyroid carcinoma. MEN 2 subtypes have distinct mutational spectrums and vary in severity. The most severe disease subtype, MEN 2B, is associated with a specific RET mutation (M918T) that has been predicted to alter downstream signaling and target...

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Share to Multiple Endocrine Neoplasia Type 2a
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oligonucleotide Array Sequence Analysis

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Source

Identifiers

PMID: 19226610
DOI: 10.1002/gcc.20653

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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