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Article

Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 2002

Glickstein Sara B, Hof Patrick R, Schmauss Claudia

Abstract excerpt

Mice deficient for dopamine D(2) and D(3) receptors exhibit blunted c-fos responses to D(1) agonist stimulation. Stereologic cell counting revealed decreased numbers of medial prefrontal cortex neurons that express Fos immunoreactivity in all layers, particularly in the prelimbic and anterior cingulate subregions. Pretreatment of these mutants with a single, low dose of methamphetamine (METH) led to a sustained...

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Identifiers

PMID: 12097513
PMCID: PMC6758242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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