Article
Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice.
Neuroscience - 1 Jan 2003
Trinh J V, Nehrenberg D L, Jacobsen J P R, Caron M G, Wetsel W C
Abstract excerpt
Dopamine (DA) is a neurotransmitter that has been implicated in a wide variety of psychiatric disorders that include attention deficit-hyperactivity disorder (ADHD), schizophrenia, and drug abuse. Recently, we have been working with a mouse in which the gene for the DA transporter (DAT) has been disrupted. This mouse is hyperactive in the open field, displays an inability to inhibit ongoing behaviors, and is...
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