Article
Age-related behavioural phenotype and cellular characterisation of mice with progressive ablation of D1 dopamine receptor-expressing cells.
Behavioural brain research - 5 Jan 2010
Babovic Daniela, Jiang Luning, Gantois Ilse, Lawrence Andrew J, Ferreri Vincenzo, Schütz Günter, Waddington John L, Drago John
Abstract excerpt
In this study we characterize the behavioural and cellular phenotype of mutant (MUT) mice with progressive loss of D1 dopamine receptor (Drd1a)-expressing cells. Adult [14-19 weeks] MUT mice showed intact working memory in the spontaneous alternation test but evidenced anxiety-like behaviour in the elevated plus maze and the light-dark test. The ethogram of mature adult MUT [average age 22 weeks] was compared...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.