Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase.

Neuroscience - 9 Sept 2008

Babovic D, O'Tuathaigh C M, O'Connor A M, O'Sullivan G J, Tighe O, Croke D T, Karayiorgou M, Gogos J A, Cotter D, Waddington J L

Abstract excerpt

Catechol-O-methyltransferase is an important enzyme in the metabolism of dopamine and an important regulator of aspects of dopamine-dependent working memory in prefrontal cortex that are disturbed in schizophrenia. This study investigated the phenotype of mice with heterozygous deletion vs. homozygous knockout of the catechol-O-methyltransferase gene across paradigms that access processes relevant for psychotic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Cognition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Exploratory Behavior

Share to Maze Learning

Share to Memory

Share to Motor Activity

Share to Neuropsychological Tests

Share to Social Behavior

Source

Identifiers

PMID: 18674597
DOI: 10.1016/j.neuroscience.2008.07.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase.PMID 18674597Read ↗

Cognition in transmembrane domain neuregulin 1 mutant mice.Semantic proximity Read ↗

Disturbances of novel object exploration and recognition in a chronic ketamine mouse model of schizophrenia.Semantic proximity Read ↗

Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.Semantic proximity Read ↗

Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice.Semantic proximity Read ↗

Genetically modified mice related to schizophrenia and other psychoses: seeking phenotypic insights into the pathobiology and treatment of negative symptoms.Semantic proximity Read ↗

Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia.Semantic proximity Read ↗

Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1.Semantic proximity Read ↗

Impairments in social novelty recognition and spatial memory in mice with conditional deletion of Scn1a in parvalbumin-expressing cellsSemantic proximity Read ↗

Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia.Semantic proximity Read ↗

TMEM16A ablation in cholinergic medial habenula neurons induces early-onset schizophrenia-like phenotypes in mice.Semantic proximity Read ↗

Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects.Semantic proximity Read ↗

Susceptibility genes for schizophrenia: characterisation of mutant mouse models at the level of phenotypic behaviour.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.