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Article

Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase.

Neuroscience - 9 Sept 2008

Babovic D, O'Tuathaigh C M, O'Connor A M, O'Sullivan G J, Tighe O, Croke D T, Karayiorgou M, Gogos J A, Cotter D, Waddington J L

Abstract excerpt

Catechol-O-methyltransferase is an important enzyme in the metabolism of dopamine and an important regulator of aspects of dopamine-dependent working memory in prefrontal cortex that are disturbed in schizophrenia. This study investigated the phenotype of mice with heterozygous deletion vs. homoz...

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Identifiers

PMID: 18674597
DOI: 10.1016/j.neuroscience.2008.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18674597-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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