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Article

Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis.

The Journal of experimental medicine - 1 Jul 2002

Ji Hong, Pettit Allison, Ohmura Koichiro, Ortiz-Lopez Adriana, Duchatelle Veronique, Degott Claude, Gravallese Ellen, Mathis Diane, Benoist Christophe

Abstract excerpt

In spontaneous inflammatory arthritis of K/BxN T cell receptor transgenic mice, the effector phase of the disease is provoked by binding of immunoglobulins (Igs) to joint surfaces. Inflammatory cytokines are known to be involved in human inflammatory arthritis, in particular rheumatoid arthritis, although, overall, the pathogenetic mechanisms of the human affliction remain unclear. To explore the analogy between...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12093872
DOI: 10.1084/jem.20020439
PMCID: PMC2194010

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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