Article
Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.
Journal of the American Society of Nephrology : JASN - 1 Jun 2002
Rantanen Maija, Palmén Tuula, Pätäri Anu, Ahola Heikki, Lehtonen Sanna, Aström Eva, Floss Thomas, Vauti Franz, Wurst Wolfgang, Ruiz Patrizia, Kerjaschki Dontscho, Holthöfer Harry
Abstract excerpt
The molecular mechanisms maintaining glomerular filtration barrier are under intensive study. This study describes a mutant Nphs1 mouse line generated by gene-trapping. Nephrin, encoded by Nphs1, is a structural protein of interpodocyte filtration slits crucial for formation of primary urine. Nephrin(trap/trap) mutants show characteristic features of proteinuric disease and die soon after birth. Morphologically,...
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