Article
Interaction of intracellular beta amyloid peptide with chaperone proteins.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2002
Fonte Virginia, Kapulkin Wadim Jan, Kapulkin Vadim, Taft Andrew, Fluet Amy, Friedman David, Link Christopher D
Abstract excerpt
Expression of the human beta amyloid peptide (A beta) in transgenic Caenorhabditis elegans animals can lead to the formation of intracellular immunoreactive deposits as well as the formation of intracellular amyloid. We have used this model to identify proteins that interact with intracellular A beta in vivo. Mass spectrometry analysis of proteins that specifically coimmunoprecipitate with A beta has identified...
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