Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.

doi:10.1073/pnas.92.20.9368

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Article

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 1995

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Abstract excerpt

Transgenic Caenorhabditis elegans nematodes have been engineered to express potentially amyloidic human proteins. These animals contain constructs in which the muscle-specific unc-54 promoter/enhancer of C. elegans drives the expression of the appropriate coding regions derived from human cDNA clones. Animals containing constructs expressing the 42-amino acid beta-amyloid peptide (derived from human amyloid...

Topics

Amyloid beta-Peptides
Animals
Animals, Genetically Modified
Antibodies, Monoclonal
Base Sequence
Benzothiazoles
Caenorhabditis
Chimera
DNA Primers
Epitopes
Fluorescent Dyes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Immunohistochemistry

Male

Molecular Sequence Data

Prealbumin

Recombinant Fusion Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7568134
DOI: 10.1073/pnas.92.20.9368
PMCID: PMC40986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7568134-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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