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Article

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

PloS one - 1 Jan 2014

Khabirova Eleonora, Moloney Aileen, Marciniak Stefan J, Williams Julie, Lomas David A, Oliver Stephen G, Favrin Giorgio, Sattelle David B, Crowther Damian C

Abstract excerpt

The human Aβ peptide causes progressive paralysis when expressed in the muscles of the nematode worm, C. elegans. We have exploited this model of Aβ toxicity by carrying out an RNAi screen to identify genes whose reduced expression modifies the severity of this locomotor phenotype. Our initial finding was that none of the human orthologues of these worm genes is identical with the genome-wide significant GWAS...

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Identifiers

PMID: 25080104
DOI: 10.1371/journal.pone.0102985
PMCID: PMC4117641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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