Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.

Molecular cancer research : MCR - 1 Aug 2003

Harada Hideki, Nakagawa Hiroshi, Oyama Kenji, Takaoka Munenori, Andl Claudia D, Jacobmeier Birgit, von Werder Alexander, Enders Gregory H, Opitz Oliver G, Rustgi Anil K

Abstract excerpt

Normal human somatic cells have a finite life span and undergo replicative senescence after a limited number of cell divisions. Erosion of telomeric DNA has emerged as a key factor in senescence, which is antagonized during cell immortalization and transformation. To clarify the involvement of telomerase in the immortalization of keratinocytes, catalytic subunit of telomerase (hTERT) expression was restored in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclins

Share to Esophagus

Share to Genes, p16

Share to Genes, ras

Share to Keratinocytes

Share to Telomerase

Source

Identifiers

PMID: 12939398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.PMID 12939398Read ↗

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.Semantic proximity Read ↗

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cellsSemantic proximity Read ↗

Immortal phenotype of the esophageal epithelial cells in the process of immortalization.Semantic proximity Read ↗

A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.Semantic proximity Read ↗

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and CancerSemantic proximity Read ↗

Unveiling senescence-associated secretory phenotype in epidermal aging: insights from reversibly immortalized keratinocytesSemantic proximity Read ↗

Characterisation of telomerase immortalised normal human oesophageal squamous cellsSemantic proximity Read ↗

Human keratinocytes are efficiently immortalized by a Rho kinase inhibitorSemantic proximity Read ↗

The significance of telomerase activation and cellular immortalization in human cancerSemantic proximity Read ↗

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes.Semantic proximity Read ↗

Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways.Semantic proximity Read ↗

Immortalization of human small airway epithelial cells by ectopic expression of telomeraseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.