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Article

Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.

Molecular cancer research : MCR - 1 Aug 2003

Harada Hideki, Nakagawa Hiroshi, Oyama Kenji, Takaoka Munenori, Andl Claudia D, Jacobmeier Birgit, von Werder Alexander, Enders Gregory H, Opitz Oliver G, Rustgi Anil K

Abstract excerpt

Normal human somatic cells have a finite life span and undergo replicative senescence after a limited number of cell divisions. Erosion of telomeric DNA has emerged as a key factor in senescence, which is antagonized during cell immortalization and transformation. To clarify the involvement of te...

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PMID: 12939398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12939398-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.PMID 12939398Read ↗

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