p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

doi:10.1093/jnci/95.10.723

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p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

Journal of the National Cancer Institute - 21 May 2003

Sviderskaya Elena V, Gray-Schopfer Vanessa C, Hill Simon P, Smit Nico P, Evans-Whipp Tracy J, Bond Jane, Hill Lucy, Bataille Veronique, Peters Gordon, Kipling David, Wynford-Thomas David, Bennett Dorothy C

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BACKGROUND: The melanoma susceptibility locus cyclin-dependent kinase inhibitor 2A encodes two unrelated cell growth inhibitors, p16 and alternative reading frame (ARF). In fibroblasts, both proteins are implicated in cellular senescence, a key barrier to tumor development. The p16 coding sequence is more often mutated in melanoma families than is the ARF sequence. To investigate the role of p16 in melanocytes,...

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p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

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