Article
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Molecular and cellular biology - 1 Feb 2000
Dickson M A, Hahn W C, Ino Y, Ronfard V, Wu J Y, Weinberg R A, Louis D N, Li F P, Rheinwald J G
Abstract excerpt
Normal human cells exhibit a limited replicative life span in culture, eventually arresting growth by a process termed senescence. Progressive telomere shortening appears to trigger senescence in normal human fibroblasts and retinal pigment epithelial cells, as ectopic expression of the telomerase catalytic subunit, hTERT, immortalizes these cell types directly. Telomerase expression alone is insufficient to...
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