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Article

Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells.

Journal of cellular physiology - 1 Jun 2004

Kang Mo K, Kameta Ayako, Shin Ki-Hyuk, Baluda Marcel A, Park No-Hee

Abstract excerpt

We investigated the phenotypic and molecular alterations in normal human oral keratinocytes (NHOK) during in vitro replication in two different culture conditions. The cells were cultured either in chemically defined Keratinocyte Growth Medium (KGM) without feeder layers or in serum-containing flavin-adenine dinucleotide (FAD) medium with feeder layers. Primary NHOK underwent 22 +/- 3 population doublings (PDs)...

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PMID: 15095283
DOI: 10.1002/jcp.10410

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