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Article

Expression of HGF/SF and Met protein is associated with genetic alterations of VHL gene in primary renal cell carcinomas.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Mar 2002

Oh Ro Ra, Park Jik Young, Lee Jong Heun, Shin Min Sun, Kim Hong Sug, Lee Sang Kyu, Kim Young Sil, Lee Sug Hyung, Lee Sie Nae, Yang Young Mok, Yoo Nam Jin, Lee Jung Young, Park Won Sang

Abstract excerpt

We analyzed the genetic alterations of VHL, HGF/SF, and Met genes and the expression pattern of HGF/SF and Met protein in 26 renal cell carcinomas (RCCs). We found five mutations of the VHL gene and frequent LOH (50%) only in non-papillary clear cell RCC. We found six cases in which the CpG island of VHL was methylated. In addition, one missense mutation of the HGF/SF gene was detected in clear cell RCC. HGF/SF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-met

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Source

Identifiers

PMID: 12076276
DOI: 10.1034/j.1600-0463.2002.100305.x

Genes

HGF
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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