Article
HGF and MET mutations in primary and secondary lymphedema.
Lymphatic research and biology - 1 Jan 2008
Finegold David N, Schacht Vivien, Kimak Mark A, Lawrence Elizabeth C, Foeldi Etelka, Karlsson Jenny M, Baty Catherine J, Ferrell Robert E
Abstract excerpt
BACKGROUND: Lymphedema is the abnormal accumulation of protein-rich fluid in the interstitial space. Primary lymphedema is a rare genetic condition with both autosomal dominant and autosomal recessive modes of inheritance. Three genes, FLT4 (VEGFR3), FOXC2, and SOX18 cause varying forms of primary lymphedema. In industrialized countries, secondary lymphedema is usually associated with cancer therapy and/or...
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