Article
Absence of mutations in the kinase domain of the Met gene and frequent expression of Met and HGF/SF protein in primary gastric carcinomas.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Mar 2000
Park W S, Oh R R, Kim Y S, Park J Y, Shin M S, Lee H K, Lee S H, Yoo N J, Lee J Y
Abstract excerpt
Hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, Met, are known to play important roles in tumor cell migration, invasion, and metastasis. We analyzed the expression of these genes and the mutations in the kinase domain of the Met gene in 43 gastric carcinomas. Of the 43 cases, the Met and HGF/SF protein were expressed in 29 (67%) and 22 (51%), respectively. All of the cases with HGF/SF...
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