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Article

PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells.

The Journal of general virology - 1 Jul 2002

Sun Shishinn, Steinberg Bettie M

Abstract excerpt

Laryngeal papillomas are caused by infection of the laryngeal epithelium by human papillomavirus type 6 or type 11 (HPV-6/-11). Previous studies in our laboratory have demonstrated an increase in PI3 kinase levels in papilloma tissue. However, activation of the downstream effector of PI3 kinase, protein kinase B (PKB/Akt), was reduced. This observation was explained by the elevated expression of the phosphatase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12075083
DOI: 10.1099/0022-1317-83-7-1651

Genes

PTEN
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells.PMID 12075083Read ↗

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Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head and neck, despite loss of heterozygosity at this locus.Semantic proximity Read ↗

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