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Article

Single nucleotide polymorphism (SNP) allele frequency estimation in DNA pools using Pyrosequencing.

Nature protocols - 1 Jan 2006

Lavebratt Catharina, Sengul Selim

Abstract excerpt

Identifying the genetic variation underlying complex disease requires analysis of many single nucleotide polymorphisms (SNPs) in a large number of samples. Several high-throughput SNP genotyping techniques are available; however, their cost promotes the use of association screening with pooled DNA. This protocol describes the estimation of SNP allele frequencies in pools of DNA using the quantitative sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17406511
DOI: 10.1038/nprot.2006.442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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