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Article

PG13 packaging cells produce recombinant retroviruses carrying a diphtheria toxin mutant which kills cancer cells.

Journal of virology - 1 Jul 2002

Qiao Jian, Caruso Manuel

Abstract excerpt

The development of suicide gene therapy with gene products that are directly toxic to cells, such as the A subunit of diphtheria toxin (DT-A), has been hampered by the difficulty of engineering recombinant viruses. DT-A is a strong inhibitor of protein synthesis that acts by ADP-ribosylating elongation factor 2, and a low level of DT-A expression in virus producer cells prevents the production of recombinant...

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Identifiers

PMID: 12072533
DOI: 10.1128/jvi.76.14.7343-7348.2002
PMCID: PMC136312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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