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Article

Use of H19 Gene Regulatory Sequences in DNA-Based Therapy for Pancreatic Cancer

1 Jan 2010

Abstract excerpt

Pancreatic cancer is the eighth most common cause of death from cancer in the world, for which palliative treatments are not effective and frequently accompanied by severe side effects. We propose a DNA-based therapy for pancreatic cancer using a nonviral vector, expressing the diphtheria toxin A chain under the control of the H19 gene regulatory sequences. The H19 gene is an oncofetal RNA expressed during embryo...

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Identifiers

PMID: 21052499
DOI: 10.1155/2010/178174

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