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High-titer packaging cells producing recombinant retroviruses resistant to human serum

1 Dec 1995

Abstract excerpt

Novel retroviral protein expression constructs were designed to retain minimal retroviral sequences and to express dominant selectable markers by reinitiation of translation after expression of the viral genes. HT1080 cells were selected as producer cells for their ability to release high-titer viruses that are resistant to inactivation by human serum. Two HT1080-based packaging cell lines which produce Moloney...

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PMID: 7494248
DOI: 10.1128/jvi.69.12.7430-7436.1995

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