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Article

Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity

28 Aug 2019

Abstract excerpt

OBJECTIVE: Melanin-concentrating hormone (MCH) plays a key role in regulating energy balance. MCH acts via its receptor MCHR1, and MCHR1 deletion increases energy expenditure and locomotor activity, which is associated with a hyperdopaminergic state. Since MCHR1 expression is widespread, the neurons supporting the effects of MCH on energy expenditure are not clearly defined. There is a high density of MCHR1...

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PMID: 31668382
DOI: 10.1016/j.molmet.2019.08.018

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