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Article

Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2006

Roy Madhuri, David Nadia K, Danao Jean V, Baribault Helene, Tian Hui, Giorgetti Marco

Abstract excerpt

The biological effects of the melanin-concentrating hormone (MCH) are mediated by the melanin concentrating hormone receptor 1 (MCHR1) in mice. This receptor is enriched in brain areas that are involved in the modulation of mood and affect, suggesting that MCH-dependent signaling may influence neurobiological mechanisms underlying fear and anxiety processes. To test this, we have generated mice lacking functional...

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Source

Identifiers

PMID: 15988472
DOI: 10.1038/sj.npp.1300805

Genes

MCHR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects.PMID 15988472Read ↗

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