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Article

Tyrosine 759 of the cytokine receptor gp130 is involved in Listeria monocytogenes susceptibility.

Genes and immunity - 1 May 2002

Kamimura D, Fu D, Matsuda Y, Atsumi T, Ohtani T, Park S J, Ishihara K, Hirano T

Abstract excerpt

Interleukin-6 family cytokines have been implicated in adaptive and innate immunity, hematopoiesis, and inflammation. This cytokine family shares a signal-transducing receptor subunit called gp130. gp130(F759/F759) knockin mice carry a point mutation at the SHP2-binding site of gp130 due to the replacement of tyrosine-759 (Y759 for human gp130) with phenylalanine (F). To explore the effect of this point mutation...

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Identifiers

PMID: 12070777
DOI: 10.1038/sj.gene.6363825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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