Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice.

BMC musculoskeletal disorders - 19 Feb 2009

Tsuji Fumio, Yoshimi Miwa, Katsuta Osamu, Takai Miwa, Ishihara Katsuhiko, Aono Hiroyuki

Abstract excerpt

BACKGROUND: Knock-in mice (gp130F759) with a Y759F point mutation in gp130, a signal transducing receptor subunit shared by members of the IL-6 cytokine family, show sustained activation of STAT3, enhanced acute-phase or immune responses, and autoimmune arthritis. We conducted a detailed analysis of collagen-induced arthritis (CIA) in gp130F759 with a DBA/1J background (D/J.gp130F759). METHODS: We backcrossed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antirheumatic Agents
Share to Arthritis, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokine Receptor gp130

Share to Glomerulonephritis

Share to Hyperplasia

Share to Joints

Share to Lymphoid Tissue

Share to Methotrexate

Source

Open in PubMed Open full text

Identifiers

PMID: 19228423
DOI: 10.1186/1471-2474-10-23
PMCID: PMC2652421

Genes

STAT3
MIP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice.PMID 19228423Read ↗

IL-6-PAD4 axis in the earliest phase of arthritis in knock-in gp130F759 mice, a model for rheumatoid arthritisSemantic proximity Read ↗

Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.Semantic proximity Read ↗

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis.Semantic proximity Read ↗

Acquiring signalling specificity from the cytokine receptor gp130.Semantic proximity Read ↗

Understanding complex formation of gp130 cytokines for the design of selective therapeutics.Semantic proximity Read ↗

IL-6 signal transduction and its physiological roles: the signal orchestration model.Semantic proximity Read ↗

Exclusive inhibition of IL-6 trans-signaling by soluble gp130FlyRFcSemantic proximity Read ↗

Signaling modality within gp130 receptor enhances tissue regenerationSemantic proximity Read ↗

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritisSemantic proximity Read ↗

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.Semantic proximity Read ↗

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosisSemantic proximity Read ↗

The SKG Mutation in ZAP-70 also Confers Arthritis Susceptibility in C57 Black Mouse Strains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.