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Article

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.

The Biochemical journal - 1 Jun 2003

Fairlie W Douglas, De Souza David, Nicola Nicos A, Baca Manuel

Abstract excerpt

Cytokines of the interleukin-6 family utilize the shared cytokine receptor gp130 in the formation of active signalling complexes. Tyrosine-757 (Y757) on this receptor is critical for negative regulation of gp130-mediated signalling. Two signalling regulators, suppressor of cytokine signalling 3 (SOCS3) and Src homology 2 domain-containing tyrosine phosphatase-2 (SHP2), are recruited to Y757 following receptor...

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Share to Cytokine Receptor gp130
Share to Luciferases
Share to Protein Phosphatase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Receptors, Erythropoietin

Share to src Homology Domains

Share to Suppressor of Cytokine Signaling 3 Protein

Share to Suppressor of Cytokine Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12593670
DOI: 10.1042/BJ20030104
PMCID: PMC1223392

Genes

SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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